Estimate of maintenance EPO to darbepoetin alfa dose conversion ratio in a hospital-based dialysis patient population

The objective is to describe dose conversion methods that take into account the non-proportional dose relationship between EPO and darbepoetin alfa, and calculate the dose conversion ratio (DCR) between the two ESAs in a hospital-based dialysis patient population.
Clinical trial data indicate that the relationship between EPO and darbepoetin alfa is non-proportional (non-linear) across the dosing spectrum; darbepoetin alfa is more efficient with increasing EPO doses. This non-proportional dose relationship is recognized in the dose conversion table included in the darbepoetin alfa U.S. package insert.



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